Understanding Depression

Major depressive disorder (depression) is a serious medical condition with a broad range of symptoms. Emotional symptoms can include sadness, loss of interest in things you once enjoyed, thoughts of death or suicide, and feelings of guilt or worthlessness. Physical symptoms can include restlessness or slowness of speech, thought, or activity; trouble concentrating or making decisions; lack of energy; and changes in weight/appetite or sleep. Associated symptoms of depression may include aches and pains, tearfulness, constant worry, dwelling on negative thoughts, constantly turning things over in your mind, irritability, and anxiety.

There are many theories about the cause of depression. One common theory is that depression is caused by an imbalance of naturally occurring substances in the brain.

How Cymbalta Is Believed to Work

Although the exact way that Cymbalta works in people is unknown, it is believed to be related to an increase in the activity of serotonin and norepinephrine which are two naturally occurring substances in the brain.

Where Does Depression Hurt?

Someone with depression might think or say any of the following:

  • "I feel sad all the time and just don't feel like myself."
  • "I don't enjoy being with my friends or doing any of the things I usually love to do."
  • "I've been having a lot of trouble sleeping lately."
  • "Sometimes I feel like my life is not worth living anymore."
  • "I feel like I don't have any energy."
  • "I'm not really interested in eating."
  • "Even after a long day, I still feel restless."
  • "I feel so indecisive and I can't make any decisions."
  • "I just feel so worthless."

Seek Help

Many people suffer in silence with depression. Some are ashamed or afraid to seek help; others try to downplay the severity of their symptoms. It's important to remember that depression isn't something that's "all in your head."

Learn about the symptoms of depression.

Take Suicidal Thoughts Seriously

Thoughts about death or suicide are not uncommon in depression, and it's important to take such thoughts seriously. If you feel like giving up or as if you might hurt yourself, get help immediately:

  • Call your doctor
  • Go to the emergency room
  • Call 911
  • Call the National Suicide Prevention Lifeline, 1-800-SUICIDE [1-800-784-2433]

Family History May Be Important

People with a family history of depression may be more likely to get the disease, but anyone can become depressed. Sometimes the triggers are external–for example, relationship troubles or financial problems. At other times the disease may begin with physical illness or hormonal shifts. Depression also may occur without any identifiable trigger at all.

Who Does Depression Hurt?

Depression is common, affecting about 121 million people worldwide. It is a condition that impacts individuals of all races, ethnicities, and income levels.

Unfortunately, many people with depression avoid seeking treatment because they worry what others will think of them. They may not realize how widespread this medical condition is:

  • Depression is among the leading causes of disability worldwide
  • Women are nearly twice as likely as men to experience depression in their childbearing years
  • People with a family history of depression may be more likely to develop the disease
  • People with chronic or debilitating medical conditions may also be susceptible to the disease

Depression may affect people who don't have any obvious risk factors.

To learn more about how depression may impact your life, complete the Depression Impact Tool and get tips to learn more about partnering with your doctor.

To find help if you think a friend or loved one is depressed, learn more about supporting someone with depression.