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Science of Depression

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Learn About Cymbalta


Cymbalta is approved by the FDA for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), and for the management of diabetic peripheral neuropathic pain (DPNP).

Cymbalta can offer relief from a broad range of symptoms of depression that may include loss of interest, associated anxiety, aches and pains, and mood. Studies show that recognition and treatment of a broad range of symptoms of depression may increase your chances of relief. If you find that you are starting to feel better after taking Cymbalta, talk with your doctor about how long you should continue treatment. Do not stop taking your medicine until you speak to your doctor directly. He or she may decide to steadily reduce your dose. If you stop taking your medicine suddenly, you may experience dizziness, nausea, headache, or other potential symptoms.

There are many theories about the cause of depression. One of the most commonly accepted theories suggests that two naturally occurring chemicals, serotonin and norepinephrine, are believed to affect core mood and pain symptoms of depression.

These chemical messengers aid communication between many areas of the brain and spinal cord that affect emotional aspects of a person's nature. They are also important in "controlling the volume" of messages about pain between the body and the brain.

While the mechanism of action for Cymbalta is not fully known, its effects on depression may be due to increasing the activity of two chemicals in the central nervous system, serotonin and norepinephrine. Cymbalta is in a class of medications called selective SNRIs (serotonin and norepinephrine reuptake inhibitors), and is FDA—approved for the treatment of depression. More than 7 million patients in the United States have been prescribed Cymbalta for any indication.

Cymbalta comes in a capsule and can be taken once a day. The target daily dose for Cymbalta is 60 mg. However, your doctor may prescribe a different dose based on his or her medical judgment. Cymbalta is available in 20-mg, 30-mg and 60-mg capsules. Cymbalta is not recommended for those under 18.

Learn more about Cymbalta using the links below, and print out these pages to discuss the information with your doctor or healthcare professional:

How Cymbalta Works—Learn how Cymbalta is believed to treat your depression.
What to Expect From Cymbalta—Read about what you may experience within the first few weeks of treatment as well as how you know Cymbalta is working for you.
Safety Information—This page will provide you with safety information you should be aware of when taking Cymbalta.
Side Effects—This page will provide you with information about some common side effects associated with Cymbalta, such as nausea, dry mouth, constipation, decreased appetite, fatigue, sleepiness, and increased sweating.
Frequently Asked Questions—You can use this page as a resource when deciding what to discuss with your doctor. Find answers to some common questions here.
Prescribing Information —Here you will find detailed information about Cymbalta, how it works, and its side effects.

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