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Science of Depression

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Symptoms & Causes of Depression

Symptoms of Depression

Some of the most recognized symptoms of depression include a profound feeling of sadness or loss of interest. You may be surprised to learn that people with depression often experience a broad range of other symptoms.

In general, if you've been experiencing some combination of the following emotional or physical symptoms for more than two weeks, and they clearly interfere with your life, discuss your concerns with your doctor:

  • Sadness throughout the day, nearly every day
  • Loss of interest in or enjoyment of your favorite activities
  • Feeling of worthlessness
  • Excessive or inappropriate feelings of guilt
  • Thoughts of death or suicide
  • Trouble making decisions
  • Fatigue or lack of energy
  • Sleeping too much or too little
  • Change in appetite or weight
  • Trouble concentrating
  • Aches and pains
  • Restlessness


Don't let this list of symptoms scare you. Treatments and therapies are available to help with the symptoms of depression.

Causes of Depression

There's no simple explanation why people experience depression. It's a complex disease that may develop for a variety of reasons. It can affect anyone at any age, regardless of gender, race, ethnicity, or income level.

Some people become depressed after a major life change—the death of a loved one, a divorce, the loss of a job, or a move. Even seemingly happy events, such as becoming a parent or getting married, can trigger depression. Or, even a smaller change can sometimes trigger depression.

Some risk factors for depression include: It is important to seek help if you think you are depressed.

Get tips on talking to your doctor about depression.

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