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Science of Depression

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How Cymbalta Works


For the treatment of depression, Cymbalta offers relief from many symptoms of depression that may include loss of interest, associated anxiety, aches and pains, and mood. While the mechanism of action for Cymbalta is not fully known, its effects on depression may be due to increasing the activity of two chemicals in the central nervous system, serotonin and norepinephrine. Cymbalta is in a class of medications called selective SNRIs (serotonin and norepinephrine reuptake inhibitors), and is FDA-approved for the treatment of depression. More than 7 million patients in the United States have been prescribed Cymbalta for any indication.

The Science of Depression

There are many theories about the cause of depression. One of the most commonly accepted theories suggests that two naturally occurring chemicals, serotonin and norepinephrine, are believed to affect core mood and pain symptoms of depression.

These chemical messengers aid communication between many areas of the brain that affect emotional aspects of a person's nature. They are also important in "controlling the volume" of messages about pain between the body and the brain.

Cymbalta is not a narcotic.

You can also read the full Prescribing Information for details about Cymbalta.

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