Common Questions About Treatment

Starting treatment can be an important first step for the person with depression. Treatment can be either medication, therapy, or both. But treatment can raise a number of questions for everyone involved.

How soon will my friend or family member start to feel better?
Getting better doesn't happen overnight. It happens gradually. With some medications, many people may begin to see improvement of their symptoms of depression within one to four weeks. With most antidepressants, it can take up to four to six weeks of consistent treatment to feel the full benefit of the medication. Of course, the timing can vary depending on the antidepressant and the individual. Your friend or family member should continue to take his or her medication according to the doctor's instructions.

Will there be any side effects to Cymbalta?
All medications have side effects, but everyone responds differently to medications. Talk to your physician about any concerns you may have about your medication. The three most commonly reported side effects of Cymbalta include:

These side effects were reported during clinical trials of depression. This is not a complete list of side effects. For complete safety information, please read the full Safety Information and Boxed Warning.

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Will being on an antidepressant change my loved one's personality?
No. What medication will do is help improve the symptoms of depression that your loved one may be experiencing. It won't change who that person is.

Who will be in charge of monitoring my friend or family member's progress?
If the person is taking an antidepressant, he or she should be checking in with a healthcare professional to assess how the medication is working and discuss any side effects. That may be the person's primary care physician, or it may be a specialist, such as a psychiatrist. In addition, your loved one may be undergoing psychotherapy with a different healthcare professional, such as a psychologist or licensed clinical social worker.

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What if the medication isn't working or my loved one doesn't take it as prescribed?
To feel the full benefits of an antidepressant, it must be taken as prescribed for an adequate length of time. Many people don't give their antidepressant medication enough time to do its job properly. Encourage your loved one to talk to the doctor before they stop taking the medication.

If the doctor does recommend taking your loved one off medication, he or she will probably advise decreasing the dose slowly. Some antidepressants can cause uncomfortable side effects if stopped abruptly, which is why he or she should not stop taking medication without talking to the doctor.

However, it is vital to first give the medication enough time to work. People are often tempted to stop taking their medication as soon as they start to feel better. Or they think they can take days off. But antidepressants aren't like aspirin—they shouldn't be taken sporadically. Studies suggest that treatment with antidepressants can reduce the risk that the depression will return. Treatment guidelines recommend continuing treatment for at least a further 6 months to minimize the risk of relapse. The National Institute of Mental Health (NIMH) suggests that some patients, such as those with chronic depression or those who have experienced multiple episodes of depression, may need to stay on antidepressant medication indefinitely. People may need to be periodically assessed by their doctor to determine their need for longer term treatment.

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Important Safety Information About Cymbalta

Antidepressants can increase suicidal thoughts and behaviors in children, teens, and young adults. Suicide is a known risk of depression and some other psychiatric disorders. Call your doctor right away if you have new or worsening depression symptoms, unusual changes in behavior, or thoughts of suicide. Be especially observant within the first few months of treatment or after a change in dose. Approved only for adults 18 and over.

What should I talk about with my healthcare provider?

Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, unusual changes in behavior, thoughts of suicide, anxiety, agitation, panic attacks, difficulty sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness, or extreme hyperactivity. Call your healthcare provider right away if you have thoughts of suicide or if any of these symptoms are severe or occur suddenly. Be especially observant within the first few months of antidepressant treatment or whenever there is a change in dose.

Who should NOT take Cymbalta?

You should not take Cymbalta if:

  • You have recently taken a type of antidepressant called a monoamine oxidase inhibitor (MAOI)
  • You have uncontrolled narrow-angle glaucoma (increased eye pressure)
  • You are taking Mellaril® (thioridazine)

What other important information should I discuss with my healthcare provider?

Before starting Cymbalta, talk with your healthcare provider:

  • about all of your medical conditions, including kidney or liver problems, glaucoma, diabetes, seizures, or if you have bipolar disorder. Cymbalta may worsen a type of glaucoma or the control of blood sugar in some patients with diabetes
  • about your alcohol use
  • if you are taking nonprescription or prescription medicines, including those for migraine, to address a possible life-threatening condition
  • if you are taking NSAID pain relievers, aspirin, or blood thinners. Use with Cymbalta may increase bleeding risk
  • if you are pregnant, plan to become pregnant during therapy, or are breastfeeding an infant

While taking Cymbalta, talk with your healthcare provider:

  • if you have itching, right upper belly pain, dark urine, yellow skin/eyes, or unexplained flu-like symptoms, which may be signs of liver problems. Severe liver problems, sometimes fatal, have been reported
  • if you have high fever, confusion, and stiff muscles to address a possible life-threatening condition
  • before stopping Cymbalta or changing your dose
  • if you experience dizziness or fainting upon standing, especially when first starting Cymbalta or when increasing the dose
  • about your blood pressure. Cymbalta can increase your blood pressure. Your healthcare provider should check your blood pressure prior to and while taking Cymbalta
  • if you experience headache, weakness, confusion, problems concentrating, memory problems, or feel unsteady while taking Cymbalta which may be signs of low sodium levels
  • if you develop problems with urine flow

If you have any questions, talk to your healthcare provider before taking Cymbalta.

What are the possible side effects of Cymbalta?

The most common side effect of Cymbalta was nausea. Other common side effects included dry mouth, sleepiness, constipation, decreased appetite, and, increased sweating. This is not a complete list of side effects.

Other safety information about Cymbalta:

Cymbalta may cause sleepiness and dizziness. Until you know how Cymbalta affects you, you should not drive a car or operate hazardous machinery.

Please read additional Safety Information and Boxed Warning for a complete list.

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