Depression Frequently Asked Questions

  1. What is depression?
  2. What causes depression?
  3. How do women experience depression?
  4. What are the treatment options for depression?
  5. What important information should be discussed with a healthcare provider about managing depression?

1. What is depression?
Depression is a serious medical condition with a variety of symptoms. Emotional symptoms can include sadness, loss of interest in things you once enjoyed, thoughts of death or suicide, feelings of guilt or worthlessness. Physical symptoms can include restlessness, and trouble concentrating or making decisions, lack of energy, and changes in weight, appetite, or sleep patterns. Additional symptoms of depression may include tearfulness, excessive worry over physical health, brooding, excessive rumination, fatigue, irritability, and anxiety.

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2. What causes depression?
There are many theories about the cause of depression. One common theory is that depression is caused by an imbalance of naturally occurring substances in the brain and spinal cord.

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3. How do women experience depression?
Typically, more women experience depression than men. There may be many reasons for this difference, including biological, life cycle, hormonal, and psychosocial factors. While research has shown hormones have a direct effect on the brain chemistry that controls mood, scientists are still unsure why some women develop depression and others do not.

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4. What are the treatment options for depression?
Your primary care physician or a psychiatrist can provide a comprehensive treatment plan—seeing a healthcare professional is a great first step toward getting better. Before diagnosing you with depression, the doctor will get a complete diagnostic evaluation, including a family history (if any) of depression and symptom history. Symptom history will include severity and duration of symptoms, as well as when the symptoms first began.

Once a healthcare professional has diagnosed someone with depression, they may recommend a number of treatment options. Medication and talk therapy are two of the most common methods of managing depression.

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5. What important information should be discussed with a healthcare provider about managing depression?

Questions to ask your healthcare provider include:

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Take the First Step

Take that important first step in getting help for depression. Don't wait—depression is an illness that can, and should, be treated.

Talk to a loved one or a friend today about how you are feeling so they may help you talk with a doctor. In fact, print out your results from the Depression Impact Tool to help start the conversation with a friend or loved one.

Learn more about:

Indication

Cymbalta is indicated for the treatment of major depressive disorder (MDD). The efficacy of Cymbalta was established in four short-term and one maintenance trial in adults.

Cymbalta is indicated for the treatment of generalized anxiety disorder (GAD). The efficacy of Cymbalta was established in three short-term and one maintenance trial in adults.

Cymbalta is indicated for the management of diabetic peripheral neuropathic pain (DPNP) and fibromyalgia.

Important Safety Information About Cymbalta

Antidepressants can increase suicidal thoughts and behaviors in children, teens, and young adults. Suicide is a known risk of depression and some other psychiatric disorders. Call your doctor right away if you have new or worsening depression symptoms, unusual changes in behavior, or thoughts of suicide. Be especially observant within the first few months of treatment or after a change in dose. Approved only for adults 18 and over.

What should I talk about with my healthcare provider?

Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, unusual changes in behavior, thoughts of suicide, anxiety, agitation, panic attacks, difficulty sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness, or extreme hyperactivity. Call your healthcare provider right away if you have thoughts of suicide or if any of these symptoms are severe or occur suddenly. Be especially observant within the first few months of antidepressant treatment or whenever there is a change in dose.

Who should NOT take Cymbalta?

You should not take Cymbalta if:

  • You have recently taken a type of antidepressant called a monoamine oxidase inhibitor (MAOI)
  • You have uncontrolled narrow-angle glaucoma (increased eye pressure)
  • You are taking Mellaril® (thioridazine)

What other important information should I discuss with my healthcare provider?

Before starting Cymbalta, talk with your healthcare provider:

  • about all of your medical conditions, including kidney or liver problems, glaucoma, diabetes, seizures, or if you have bipolar disorder. Cymbalta may worsen a type of glaucoma or the control of blood sugar in some patients with diabetes
  • about your alcohol use
  • if you are taking nonprescription or prescription medicines, including those for migraine, to address a possible life-threatening condition
  • if you are taking NSAID pain relievers, aspirin, or blood thinners. Use with Cymbalta may increase bleeding risk
  • if you are pregnant, plan to become pregnant during therapy, or are breastfeeding an infant

While taking Cymbalta, talk with your healthcare provider:

  • if you have itching, right upper belly pain, dark urine, yellow skin/eyes, or unexplained flu-like symptoms, which may be signs of liver problems. Severe liver problems, sometimes fatal, have been reported
  • if you have high fever, confusion, and stiff muscles to address a possible life-threatening condition
  • before stopping Cymbalta or changing your dose
  • if you experience dizziness or fainting upon standing, especially when first starting Cymbalta or when increasing the dose
  • about your blood pressure. Cymbalta can increase your blood pressure. Your healthcare provider should check your blood pressure prior to and while taking Cymbalta
  • if you experience headache, weakness, confusion, problems concentrating, memory problems, or feel unsteady while taking Cymbalta which may be signs of low sodium levels
  • if you develop problems with urine flow

If you have any questions, talk to your healthcare provider before taking Cymbalta.

What are the possible side effects of Cymbalta?

The most common side effect of Cymbalta was nausea. Other common side effects included dry mouth, constipation, sleepiness, increased sweating, decreased appetite, dizziness, and weakness. This is not a complete list of side effects.

Other safety information about Cymbalta:

Cymbalta may cause sleepiness and dizziness. Until you know how Cymbalta affects you, you should not drive a car or operate hazardous machinery.

Please read additional Safety Information and Boxed Warning for a complete list.

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