Glossary

Below are definitions for a number of terms found on Cymbalta.com.

acupuncture—A form of complementary or alternative medicine that consists of inserting small needles into the skin in order to relieve pain and other symptoms.

antidepressants—A group of medications that are thought to relieve symptoms of depression by affecting the level of chemicals, known as neurotransmitters, in the brain.

biofeedback—A form of complementary or alternative medicine that uses electronic monitoring devices to help teach a patient how to relax and control pain symptoms.

blood glucose management—Taking care—through diet and/or medication—of the level of sugar found in the blood. Blood glucose management is especially important for patients with diabetes.

clinical trial—A medical study that evaluates the safety and effectiveness of a treatment or drug. Each trial is designed to answer scientific questions and to find better ways to treat people with a specific illness.

contraindication—Refers to a situation when a drug, procedure, or treatment should not be used, because it may be harmful to the person.

diabetic nerve pain—A symptom of nerve damage that occurs in people with diabetes. Symptoms can include burning, stabbing, or shooting pain; numbness; tingling or pain; and weakness in the toes, feet, legs, hands, arms, and fingers. Symptoms last throughout the day.

fibromyalgia—Fibromyalgia is characterized by chronic widespread pain in both sides of the body above and below the waistline and multiple tender points.

FDA (Food and Drug Administration)—A governmental organization responsible for protecting public health by ensuring, among other things, that medications are safe and effective.

generalized anxiety disorder—Generalized anxiety disorder (GAD) is a medical condition defined as excessive anxiety and worry, present more days than not for at least six months.

major depression—Also known as major depressive disorder. A medical condition characterized by persistent emotional symptoms, such as sadness, loss of pleasure, feelings of hopelessness and worthlessness, and thoughts of suicide or death, as well as loss of interest in things you once enjoyed.

meditation—A process of concentration and relaxation, sometimes used to help relieve pain symptoms.

narcotic—A medication that is often used to relieve pain symptoms and can lead to dependence.

neurotransmitters—Chemical "messengers" that facilitate communication between nerve cells. Neurotransmitters are found in the brain and throughout the body along pathways to the brain, such as the spinal cord. Many experts believe that neurotransmitters, such as serotonin and norepinephrine, may play a major role in regulating a person's moods, emotions, and perception of pain.

norepinephrine—A chemical messenger, or neurotransmitter, that aids communication in areas of the brain and spinal cord and may play a role in regulating a person's moods, emotions, and perception of pain.

psychiatrist—A physician that specializes in evaluating and treating mental, emotional, or behavioral disorders. Psychiatrists are medical doctors and can prescribe medication.

psychologist—A healthcare professional that specializes in the science of mind and behavior. Psychologists usually have a PhD and have received additional training to work with patients. Psychologists are not medical doctors and cannot ordinarily prescribe medication. They do perform evaluations, use psychotherapy, and may work with medical doctors to treat patients.

psychotherapist—A general term used to describe a person who practices any kind of psychotherapy.

psychotherapy—Also known as counseling or "talk" therapy. One of several possible treatments for depression, psychotherapy aims to help a person learn about himself or herself, understand past and present relationships, and change patterns of behavior that may contribute to depression. Psychotherapy can involve individual, group, or family sessions.

serotonin—A chemical messenger, or neurotransmitter, that aids communication in areas of the brain and spinal cord and may play a role in regulating a person's moods, emotions, and perception of pain.

SNRI (serotonin and norepinephrine reuptake inhibitors)—A class of medications that affect the activity of serotonin and norepinephrine.

SSRI (selective serotonin reuptake inhibitor)—A class of antidepressants that affect the activity of serotonin.

Indication

Cymbalta is indicated for the treatment of major depressive disorder (MDD). The efficacy of Cymbalta was established in four short-term and one maintenance trial in adults.

Cymbalta is indicated for the treatment of generalized anxiety disorder (GAD). The efficacy of Cymbalta was established in three short-term and one maintenance trial in adults.

Cymbalta is indicated for the management of diabetic peripheral neuropathic pain (DPNP) and fibromyalgia.

Important Safety Information About Cymbalta

Antidepressants can increase suicidal thoughts and behaviors in children, teens, and young adults. Suicide is a known risk of depression and some other psychiatric disorders. Call your doctor right away if you have new or worsening depression symptoms, unusual changes in behavior, or thoughts of suicide. Be especially observant within the first few months of treatment or after a change in dose. Approved only for adults 18 and over.

What should I talk about with my healthcare provider?

Patients on antidepressants and their families or caregivers should watch for new or worsening depression symptoms, unusual changes in behavior, thoughts of suicide, anxiety, agitation, panic attacks, difficulty sleeping, irritability, hostility, aggressiveness, impulsivity, restlessness, or extreme hyperactivity. Call your healthcare provider right away if you have thoughts of suicide or if any of these symptoms are severe or occur suddenly. Be especially observant within the first few months of antidepressant treatment or whenever there is a change in dose.

Who should NOT take Cymbalta?

You should not take Cymbalta if:

  • You have recently taken a type of antidepressant called a monoamine oxidase inhibitor (MAOI)
  • You have uncontrolled narrow-angle glaucoma (increased eye pressure)
  • You are taking Mellaril® (thioridazine)

What other important information should I discuss with my healthcare provider?

Before starting Cymbalta, talk with your healthcare provider:

  • about all of your medical conditions, including kidney or liver problems, glaucoma, diabetes, seizures, or if you have bipolar disorder. Cymbalta may worsen a type of glaucoma or the control of blood sugar in some patients with diabetes
  • about your alcohol use
  • if you are taking nonprescription or prescription medicines, including those for migraine, to address a possible life-threatening condition
  • if you are taking NSAID pain relievers, aspirin, or blood thinners. Use with Cymbalta may increase bleeding risk
  • if you are pregnant, plan to become pregnant during therapy, or are breastfeeding an infant

While taking Cymbalta, talk with your healthcare provider:

  • if you have itching, right upper belly pain, dark urine, yellow skin/eyes, or unexplained flu-like symptoms, which may be signs of liver problems. Severe liver problems, sometimes fatal, have been reported
  • if you have high fever, confusion, and stiff muscles to address a possible life-threatening condition
  • before stopping Cymbalta or changing your dose
  • if you experience dizziness or fainting upon standing, especially when first starting Cymbalta or when increasing the dose
  • about your blood pressure. Cymbalta can increase your blood pressure. Your healthcare provider should check your blood pressure prior to and while taking Cymbalta
  • if you experience headache, weakness, confusion, problems concentrating, memory problems, or feel unsteady while taking Cymbalta which may be signs of low sodium levels
  • if you develop problems with urine flow

If you have any questions, talk to your healthcare provider before taking Cymbalta.

What are the possible side effects of Cymbalta?

The most common side effect of Cymbalta was nausea. Other common side effects included dry mouth, constipation, sleepiness, increased sweating, decreased appetite, dizziness, and weakness. This is not a complete list of side effects.

Other safety information about Cymbalta:

Cymbalta may cause sleepiness and dizziness. Until you know how Cymbalta affects you, you should not drive a car or operate hazardous machinery.

Please read additional Safety Information and Boxed Warning for a complete list.

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